I am having similar problems with this issue.

My problem is a bit similar, but now the same.

In QtCreator I get the same messages:

Unable to read symbols for "QtGui.framework/Versions/4/QtGui" (file not found).
Unable to read symbols from "QtGui" (not yet mapped into memory).
Unable to read symbols for "QtCore.framework/Versions/4/QtCore" (file not found).
Unable to read symbols from "QtCore" (not yet mapped into memory).

even after doing setting up my app bundle like this:
http://doc.trolltech.com/4.3/deployment-mac.html

If I put Creator in Debug mode and toggle a breakpoint, it skip them even if they are in Qt or non-Qt forms...

BUT...
...if I compile the project HelloWorld showed here:
http://www.youtube.com/watch?v=pPp35CbVLKE

And try to debug it, the previous messages appear, but it debug without any problem...

Could anyone tell me what is different in between my code and this example that is not allowing me to debug?
(I did not use designer like him to generate the windows, I've made it manually creating my class MainWindow subclassing from QMainWindow)

Any help or hint?

Thanks guys...