Thanks norobro, it works fine and I'm using it.
I have tested another way by making this little "good blood" hack:

Qt Code: 
  1. class MyTableWidgetItem : public QTableWidgetItem
  2. {
  3. public:
  4. 	explicit MyTableWidgetItem(const QString & text, int type = Type) : QTableWidgetItem(text, type) {}
  5.  
  6. 	virtual void setData(int role, const QVariant &value)
  7. 	{
  8. 		if (QAbstractTableModel *model = (this->tableWidget() ? qobject_cast<QAbstractTableModel*>(this->tableWidget()->model()) : 0)) {
  9. 			model->blockSignals(true);
  10. 			QVariant nullValue;
  11. 			QTableWidgetItem::setData(role,nullValue);
  12. 			model->blockSignals(false);
  13. 		}		
  14. 		QTableWidgetItem::setData(role,value);
  15. 	}
  16. };
  17.  
  18. //--
  19.  
  20. QTableWidgetTest::QTableWidgetTest(QWidget *parent, Qt::WFlags flags)
  21. 	: QDialog(parent, flags)
  22. {
  23. 	ui.setupUi(this);
  24.  
  25. 	int value= 0;
  26. 	for (int row= 0; row < table->rowCount(); row++) {
  27. 		for (int col= 0; col < table->columnCount(); col++) {
  28. 			QTableWidgetItem *item= new MyTableWidgetItem(QString::number(value));
  29. 			table->setItem(row,col,item);
  30. 			value++;
  31. 		}
  32. 	}	
  33.  
  34. 	connect(ui.tableWidget,  SIGNAL(itemChanged(QTableWidgetItem*)), this,  SLOT(multipleItemsChanged(QTableWidgetItem*)));
  35. }
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