One gotcha that I have found is in handling OS-based font scaling (e.g. Windows display setting to change the default font scale to something other than 100%). If you design a form and restrict the maximum size of certain child widgets so they look "attractive", then font scaling can result in unintended clipping when the UI is shown on a different display. If you don't set a maximum size, then Qt will expand the widgets to fit their contents (usually), but the downside is that sometimes the widgets can be too wide.
Layouts will stretch their contents to fill the available space, subject to app and default constraints, and sometimes the width is just too much to make an attractive form (list or combo boxes far too wide for their contents, for example). You can control this somewhat using layout spacer items (stretch), but it is often a compromise.
So it is good to test your UI under various display conditions.
Bookmarks