I'm not sure if this answers your question, but I was able to switch from 4.2.3 to 4.3.0 on OSX by doing the following:
* unzip / tar the 4.3.0 sources to a tmp directory
./configure
make
make install (copies files to /usr/local/Trolltech/4.3.0)
./configure
make
make install (copies files to /usr/local/Trolltech/4.3.0)
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Since I compile from the bash shell, the next thing you need to do is change the PATH variable. I don't have my own .bashrc file, so I went in and changed the default one:
sudo vi /etc/profile
sudo vi /etc/profile
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Change your path to use /usr/local/Trolltech/4.3.0/bin instead of the previous version. Open a new shell to start using the new path. Be sure to run make clean and qmake again on any existing projects you have to be sure they are built with the new qmake / paths / libraries...
Colby
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