Yes, but could I use them at the same time without rebuilding QT?

I think I am not expressing myself clearly. If I understand correctly, using the two different qmake options would force me to rebuild QT each time that I switched between debug/shared and release/static. That is what I was trying to avoid.

Would switching between the two setups require rebuilding QT each time? It seems that whenever I run qmake, the previous setup is removed.